C12orf66

Across TCGA patient cohorts, C12orf66 mutation is significantly associated with the total protein of many other genes, with 36 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C12orf66-associated genes across cancer lineages are 14-3-3_beta, EGFR_pY1068, and eIF4E. Each is linked with C12orf66 in more than 1 cancer types. Because this analysis shows association rather than direction, both C12orf66-to-partner and partner-to-C12orf66 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by C12orf66-low versus C12orf66-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C12orf66→partner) and Y-score (partner→C12orf66) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.128	-3.432	.002	.005	3	1
UCEC	EGFR_pY1068 →	-0.250	-2.321	.018	.034	3	1
UCEC	eIF4E →	+0.216	+2.222	.015	.011	3	1
UCEC	ERK2 →	+0.219	+2.459	.007	.019	3	1
UCEC	Gab2 →	+0.328	+1.700	.030	.044	3	1
UCEC	GAPDH →	+0.613	+3.321	.007	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

14-3-3_beta by C12orf66 expression — UCEC

Explore this box plot interactively →