C12orf65

Across TCGA pan-cancer cohorts, C12orf65 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated C12orf65 data layer compared with 22 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher C12orf65 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated C12orf65 expression acts as an unfavorable survival marker, although some lineages such as LSCC and LUAD show a favorable association.

LSCC, CCRCC, and LUAD are the cancer types where C12orf65 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	OS	Tertile	All	0.959	0.661	.002	41	view →
CCRCC	OS	Median	II,III,IV	0.798	1.000	.005	37	view →
LUAD	DFS	Median	III,IV	0.922	0.409	.024	4	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

C12orf65–LSCC (OS)

Open the LSCC breakdown →