C12orf65

Across TCGA patient cohorts, C12orf65 mutation is significantly associated with the total protein of many other genes, with 3 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C12orf65-associated genes across cancer lineages are Annexin-1, Bcl-xL, and p90 RSK. Each is linked with C12orf65 in more than 1 cancer types. Because this analysis shows association rather than direction, both C12orf65-to-partner and partner-to-C12orf65 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Annexin-1 grouped by C12orf65-low versus C12orf65-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C12orf65→partner) and Y-score (partner→C12orf65) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Annexin-1 →	+0.754	+2.827	.009	.035	3	1
UCEC	Bcl-xL →	-0.191	-3.169	.030	.020	2	1
UCEC	p90 RSK →	+0.269	+3.183	.010	.010	1	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

Annexin-1 by C12orf65 expression — UCEC

Explore this box plot interactively →