C12orf65

Across TCGA cell cohorts, C12orf65 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,883 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible C12orf65-associated GO terms across cancer lineages are Regulation of DNA recombination, Translation reinitiation, and DNA integrity checkpoint signaling. Each is linked with C12orf65 in more than 11 cancer types. Because this analysis shows association rather than direction, both C12orf65-to-partner and partner-to-C12orf65 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of DNA recombination grouped by C12orf65-low versus C12orf65-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (C12orf65→partner) and Y-score (partner→C12orf65) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Regulation of DNA recombination →	+0.100	+0.537	.001	.001	3	12
UPPER_AERODIGESTIVE_TRACT	Translation reinitiation →	+0.059	+0.517	<.001	<.001	3	11
SOFT_TISSUE	DNA integrity checkpoint signaling →	+0.067	+0.455	.004	.006	2	12
BREAST	Signal transduction in response to DNA damage →	+0.069	+0.637	.001	.005	3	11
BONE	Positive regulation of DNA recombination →	+0.127	+0.656	<.001	<.001	3	11
SOFT_TISSUE	Microtubule polymerization →	+0.095	+0.459	<.001	.002	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,883 associations by consensus.

Regulation of DNA recombination by C12orf65 expression — BONE

Explore this box plot interactively →