C12orf65

Across TCGA cell cohorts, C12orf65 mutation is significantly associated with the mutation status of many other genes, with 823 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible C12orf65-associated genes across cancer lineages are PLEKHB1, C8B, and DEF6. Each is linked with C12orf65 in more than 1 cancer types. Because this analysis shows association rather than direction, both C12orf65-to-partner and partner-to-C12orf65 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PLEKHB1 grouped by C12orf65-low versus C12orf65-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C12orf65→partner) and Y-score (partner→C12orf65) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PLEKHB1 →	+5.087	+4.523	.006	.006	1	1
LARGE_INTESTINE	C8B →	+3.087	+4.392	.005	.005	1	1
LARGE_INTESTINE	DEF6 →	+4.087	+5.044	.001	.001	1	1
LARGE_INTESTINE	AOC1 →	+2.865	+4.217	.007	.007	1	1
LARGE_INTESTINE	TMEM176A →	+5.087	+4.523	.006	.006	1	1
LARGE_INTESTINE	SLC39A9 →	+5.672	+5.672	<.001	<.001	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 823 associations by consensus.

PLEKHB1 by C12orf65 expression — LARGE_INTESTINE

Explore this box plot interactively →