C12orf57

Across TCGA pan-cancer cohorts, C12orf57 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated C12orf57 data layer compared with 21 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher C12orf57 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated C12orf57 expression acts as an unfavorable survival marker.

HNSC, ACC, and LUAD are the cancer types where C12orf57 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.069	0.768	<.001	24	view →
ACC	OS	Median	All	0.273	0.802	.017	15	view →
LUAD	OS	Median	All	0.258	0.812	.004	12	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

C12orf57–HNSC (OS)

Open the HNSC breakdown →