C12orf57

Across TCGA pan-cancer cohorts, C12orf57 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated C12orf57 data layer compared with 21 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher C12orf57 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated C12orf57 expression acts as an unfavorable survival marker, although some lineages such as HNSC show a favorable association.

CCRCC, LUAD, and HNSC are the cancer types where C12orf57 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Quartile	II,III,IV	0.504	0.857	.003	42	view →
LUAD	OS	Median	All	0.881	1.000	.002	17	view →
HNSC	DFS	Median	II,III,IV	0.993	0.900	.007	12	view →
PDAC	OS	Median	III,IV	0.246	0.585	.012	9	view →
LSCC	OS	Median	III,IV	0.492	0.865	.011	5	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

C12orf57–CCRCC (OS)

Open the CCRCC breakdown →