C12orf43

Across TCGA pan-cancer cohorts, C12orf43 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated C12orf43 data layer compared with 26 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher C12orf43 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated C12orf43 expression acts as an unfavorable survival marker, although some lineages such as LSCC and HNSC show a favorable association.

CCRCC, LSCC, and HNSC are the cancer types where C12orf43 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	III,IV	0.434	0.808	.006	25	view →
LSCC	DFS	Tertile	All	1.000	0.905	.002	20	view →
HNSC	OS	Median	III,IV	0.791	0.541	.004	12	view →
LUAD	OS	Median	II,III,IV	1.000	0.807	.010	9	view →
PDAC	OS	Quartile	II,III,IV	0.781	0.440	.010	4	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

C12orf43–CCRCC (DFS)

Open the CCRCC breakdown →