C12orf43

Across TCGA patient cohorts, C12orf43 mutation is significantly associated with the RNA expression of many other genes, with 222 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C12orf43-associated genes across cancer lineages are MIR3928, LINC02840, and APOBEC3AP1. Each is linked with C12orf43 in more than 1 cancer types. Because this analysis shows association rather than direction, both C12orf43-to-partner and partner-to-C12orf43 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR3928 grouped by C12orf43-low versus C12orf43-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C12orf43→partner) and Y-score (partner→C12orf43) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MIR3928 →	+0.569	+2.994	<.001	.003	3	2
COAD	LINC02840 →	+0.185	+5.251	<.001	.003	3	2
BLCA	APOBEC3AP1 →	+0.279	+5.017	<.001	.002	3	2
LUAD	FAM197Y5 →	+0.039	+7.930	<.001	.008	3	2
UCEC	RNA5SP412 →	+0.859	+2.704	<.001	.004	3	2
SKCM	MIR525 →	+0.220	+4.328	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 222 associations by consensus.

MIR3928 by C12orf43 expression — UCEC

Explore this box plot interactively →