C12orf43

Across TCGA patient cohorts, C12orf43 mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C12orf43-associated genes across cancer lineages are INPP4B, MAPK_pT202_Y204, and mTOR_pS2448. Each is linked with C12orf43 in more than 1 cancer types. Because this analysis shows association rather than direction, both C12orf43-to-partner and partner-to-C12orf43 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, INPP4B grouped by C12orf43-low versus C12orf43-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C12orf43→partner) and Y-score (partner→C12orf43) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	INPP4B →	-0.364	-3.308	.031	.010	3	1
UCEC	MAPK_pT202_Y204 →	-0.578	-3.000	.018	.036	3	1
UCEC	mTOR_pS2448 →	-0.219	-2.980	.005	.036	3	1
UCEC	p62 Lck ligand →	+0.426	+3.321	.012	.010	3	1
UCEC	p90 RSK_pT359_S363 →	-0.248	-2.990	.019	.036	3	1
UCEC	PCNA →	+0.316	+3.321	.005	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

INPP4B by C12orf43 expression — UCEC

Explore this box plot interactively →