C12orf43

Across TCGA cell cohorts, C12orf43 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,574 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible C12orf43-associated GO terms across cancer lineages are rRNA 5'-end processing, Endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA), and Endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Each is linked with C12orf43 in more than 18 cancer types. Because this analysis shows association rather than direction, both C12orf43-to-partner and partner-to-C12orf43 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, rRNA 5'-end processing grouped by C12orf43-low versus C12orf43-high in BLOOD_Myeloma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (C12orf43→partner) and Y-score (partner→C12orf43) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	rRNA 5'-end processing →	+0.125	+0.891	.001	.002	2	19
BLOOD_Myeloma	Endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) →	+0.125	+0.891	.001	.002	2	19
BLOOD_Myeloma	Endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) →	+0.162	+1.052	<.001	.002	2	18
UPPER_AERODIGESTIVE_TRACT	DNA-templated transcription initiation →	+0.078	+0.910	.002	.001	3	16
OVARY	DNA-templated transcription elongation →	+0.089	+0.602	<.001	.002	3	16
BREAST	Positive regulation of mitotic cytokinesis →	+0.163	+0.753	.001	<.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,574 associations by consensus.

rRNA 5'-end processing by C12orf43 expression — BLOOD_Myeloma

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