C12orf4

Across TCGA pan-cancer cohorts, C12orf4 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated C12orf4 data layer compared with 25 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher C12orf4 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated C12orf4 expression acts as an unfavorable survival marker, although some lineages such as PDAC and CCRCC show a favorable association.

PDAC, CCRCC, and HNSC are the cancer types where C12orf4 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Tertile	III,IV	0.975	0.307	.001	30	view →
CCRCC	DFS	Quartile	All	1.000	0.855	.020	17	view →
HNSC	OS	Median	III,IV	0.933	0.803	.014	11	view →
LUAD	DFS	Median	II,III,IV	1.000	0.798	.015	7	view →
UCEC	DFS	Tertile	II,III,IV	0.462	0.839	.020	6	view →
GBM	DFS	Quartile	All	0.847	0.627	.037	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

C12orf4–PDAC (DFS)

Open the PDAC breakdown →