C12orf4

Across TCGA patient cohorts, C12orf4 protein abundance is significantly associated with the RNA expression of many other genes, with 10,423 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible C12orf4-associated genes across cancer lineages are CDCA4, APH1B, and CDCA5. Each is linked with C12orf4 in more than 5 cancer types. Because this analysis shows association rather than direction, both C12orf4-to-partner and partner-to-C12orf4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, C12orf4 versus CDCA4 in UCEC, with a Pearson correlation of -0.35.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C12orf4→partner) and Y-score (partner→C12orf4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CDCA4 →	-0.761	-0.212	.001	.004	3	6
OV	APH1B →	+0.703	+0.216	<.001	<.001	3	5
BRCA	CDCA5 →	-1.159	-0.271	<.001	<.001	3	5
UCEC	CDC45 →	-1.177	-0.247	<.001	<.001	3	5
LSCC	GINS1 →	-0.774	-0.182	<.001	.001	3	4
BRCA	CDC25B →	-0.712	-0.236	.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,423 associations by consensus.

C12orf4 vs CDCA4 — UCEC

Explore this scatter interactively →