C12orf4

Across TCGA patient cohorts, C12orf4 mutation is significantly associated with the RNA expression of many other genes, with 2,546 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C12orf4-associated genes across cancer lineages are MINAR2, OR52I2, and RNU6-893P. Each is linked with C12orf4 in more than 1 cancer types. Because this analysis shows association rather than direction, both C12orf4-to-partner and partner-to-C12orf4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MINAR2 grouped by C12orf4-low versus C12orf4-high in READ.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C12orf4→partner) and Y-score (partner→C12orf4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
READ	MINAR2 →	+0.083	+4.361	<.001	.006	3	2
READ	OR52I2 →	+0.036	+4.925	.001	.004	3	2
READ	RNU6-893P →	+0.733	+4.445	<.001	.005	3	2
READ	RN7SL25P →	+0.142	+4.925	<.001	.004	3	2
READ	MIR4797 →	+0.819	+5.054	<.001	.001	3	2
CESC	LINC01072 →	+0.205	+3.760	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,546 associations by consensus.

MINAR2 by C12orf4 expression — READ

Explore this box plot interactively →