C12orf4

Across TCGA patient cohorts, C12orf4 mutation is significantly associated with the total protein of many other genes, with 40 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C12orf4-associated genes across cancer lineages are Chk2_pT68, EGFR_pY1068, and eIF4E. Each is linked with C12orf4 in more than 1 cancer types. Because this analysis shows association rather than direction, both C12orf4-to-partner and partner-to-C12orf4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Chk2_pT68 grouped by C12orf4-low versus C12orf4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C12orf4→partner) and Y-score (partner→C12orf4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Chk2_pT68 →	-0.145	-3.433	.016	.005	3	2
UCEC	EGFR_pY1068 →	-0.211	-1.459	.009	.012	3	1
UCEC	eIF4E →	+0.186	+2.087	.006	.005	3	1
UCEC	A-Raf_pS299 →	-0.077	-1.584	.046	.034	3	1
UCEC	ERK2 →	+0.176	+1.847	.004	.007	3	1
UCEC	JNK_pT183_Y185 →	-0.168	-2.000	.002	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

Chk2_pT68 by C12orf4 expression — UCEC

Explore this box plot interactively →