C12orf29

Across TCGA pan-cancer cohorts, C12orf29 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated C12orf29 data layer compared with 24 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher C12orf29 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated C12orf29 expression acts as an unfavorable survival marker, although some lineages such as LSCC and HNSC show a favorable association.

CCRCC, LSCC, and HNSC are the cancer types where C12orf29 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	II,III,IV	0.396	0.803	<.001	72	view →
LSCC	DFS	Median	All	0.838	0.564	<.001	72	view →
HNSC	DFS	Median	II,III,IV	0.990	0.905	.010	9	view →
LUAD	DFS	Quartile	II,III,IV	0.985	0.704	.027	7	view →
PDAC	DFS	Median	All	0.430	0.275	.034	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

C12orf29–CCRCC (DFS)

Open the CCRCC breakdown →