C11orf98

Across TCGA pan-cancer cohorts, C11orf98 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated C11orf98 data layer compared with 29 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher C11orf98 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated C11orf98 expression acts as an unfavorable survival marker, although some lineages such as LUAD and LSCC show a favorable association.

HNSC, LUAD, and LSCC are the cancer types where C11orf98 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	III,IV	0.609	0.918	<.001	37	view →
LUAD	DFS	Median	All	0.767	0.407	<.001	14	view →
LSCC	OS	Quartile	II,III,IV	1.000	0.738	.015	13	view →
PDAC	DFS	Quartile	III,IV	0.922	0.452	.015	10	view →
COAD	DFS	Median	II,III,IV	1.000	0.881	.043	6	view →
GBM	OS	Quartile	All	0.696	0.356	.034	2	view →
CCRCC	DFS	Median	III,IV	0.355	0.742	.034	2	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

C11orf98–HNSC (DFS)

Open the HNSC breakdown →