C11orf68

Across TCGA cell cohorts, C11orf68 mutation is significantly associated with the RNA expression of many other genes, with 11 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible C11orf68-associated genes across cancer lineages are SULT6B1, PRAMEF8, and DEFB132. Each is linked with C11orf68 in more than 1 cancer types. Because this analysis shows association rather than direction, both C11orf68-to-partner and partner-to-C11orf68 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SULT6B1 grouped by C11orf68-low versus C11orf68-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C11orf68→partner) and Y-score (partner→C11orf68) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SULT6B1 →	+0.031	+4.977	<.001	.007	3	1
LARGE_INTESTINE	PRAMEF8 →	+0.326	+5.415	<.001	.004	3	1
LARGE_INTESTINE	DEFB132 →	+0.054	+5.415	<.001	.004	3	1
LARGE_INTESTINE	PRAMEF10 →	+0.919	+4.977	<.001	.007	3	1
LARGE_INTESTINE	RNASE9 →	+0.012	+4.977	<.001	.007	3	1
LARGE_INTESTINE	OR6B1 →	+0.012	+4.977	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

SULT6B1 by C11orf68 expression — LARGE_INTESTINE

Explore this box plot interactively →