C11orf65

Across TCGA patient cohorts, C11orf65 mutation is significantly associated with the total protein of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C11orf65-associated genes across cancer lineages are GAPDH, mTOR_pS2448, and PKC-b-II_pS660. Each is linked with C11orf65 in more than 1 cancer types. Because this analysis shows association rather than direction, both C11orf65-to-partner and partner-to-C11orf65 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAPDH grouped by C11orf65-low versus C11orf65-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C11orf65→partner) and Y-score (partner→C11orf65) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GAPDH →	+0.608	+2.999	.015	.035	3	2
UCEC	mTOR_pS2448 →	-0.161	-2.986	.020	.035	3	2
UCEC	PKC-b-II_pS660 →	-0.303	-2.321	.018	.034	3	2
UCEC	ATM →	-0.726	-2.584	<.001	.011	3	2
UCEC	eIF4E →	+0.264	+3.700	.007	.001	3	1
UCEC	GSK-3_pS9 →	-0.508	-2.999	.007	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

GAPDH by C11orf65 expression — UCEC

Explore this box plot interactively →