C11orf65

Across TCGA cell cohorts, C11orf65 mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible C11orf65-associated genes across cancer lineages are C3orf22, ODF4, and USP17L3. Each is linked with C11orf65 in more than 1 cancer types. Because this analysis shows association rather than direction, both C11orf65-to-partner and partner-to-C11orf65 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C3orf22 grouped by C11orf65-low versus C11orf65-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C11orf65→partner) and Y-score (partner→C11orf65) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	C3orf22 →	+0.069	+5.415	<.001	.004	3	1
SKIN	ODF4 →	+0.031	+4.977	<.001	.007	3	1
SKIN	USP17L3 →	+0.013	+5.415	<.001	.004	3	1
LARGE_INTESTINE	DEFA4 →	+0.040	+5.022	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

C3orf22 by C11orf65 expression — SKIN

Explore this box plot interactively →