C11orf58

Across TCGA pan-cancer cohorts, C11orf58 Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated C11orf58 data layer compared with 22 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in esophageal carcinoma (ESCA), where higher C11orf58 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated C11orf58 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

ESCA, PRAD, and BLCA are the cancer types where C11orf58 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ESCA	DFS	Median	All	0.098	0.533	.003	6	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →
BLCA	DFS	Median	III,IV	0.139	0.572	.026	6	view →
UCEC	DFS	Median	All	1.000	0.831	.038	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

C11orf58–ESCA (DFS)

Open the ESCA breakdown →