C11orf58

Across TCGA pan-cancer cohorts, C11orf58 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated C11orf58 data layer compared with 22 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in ovarian serous cystadenocarcinoma (OV), where higher C11orf58 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated C11orf58 expression acts as an unfavorable survival marker, although some lineages such as OV and LSCC show a favorable association.

OV, LSCC, and HNSC are the cancer types where C11orf58 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
OV	DFS	Tertile	All	1.000	0.815	.046	12	view →
LSCC	DFS	Quartile	III,IV	0.876	0.407	.024	6	view →
HNSC	DFS	Median	All	0.698	1.000	.020	5	view →
PDAC	OS	Median	II,III,IV	0.289	0.523	.016	3	view →
UCEC	OS	Quartile	All	1.000	0.819	.031	2	view →
GBM	OS	Quartile	All	0.824	0.878	.032	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

C11orf58–OV (DFS)

Open the OV breakdown →