C11orf58

Across TCGA pan-cancer cohorts, C11orf58 mass-spec protein differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of C11orf58’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where C11orf58 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types C11orf58 is over-expressed in tumor, although a few such as PDAC show the opposite, repressed pattern.

LUAD, COAD, and PDAC are the cancer types where C11orf58 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in C11orf58 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Male	II,III,IV	+0.361	<.001	9	view →
COAD	Female	All	+0.274	<.001	9	view →
PDAC	Female	All	−0.319	<.001	8	view →
LSCC	Female	All	+0.284	<.001	8	view →
HNSC	Male	IV	+0.247	<.001	8	view →
CCRCC	Male	All	+0.154	<.001	6	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

C11orf58–LUAD

Open the LUAD breakdown →