C11orf58

Across TCGA patient cohorts, C11orf58 mutation is significantly associated with the total protein of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C11orf58-associated genes across cancer lineages are TFRC, 14-3-3_beta, and EGFR_pY1068. Each is linked with C11orf58 in more than 1 cancer types. Because this analysis shows association rather than direction, both C11orf58-to-partner and partner-to-C11orf58 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TFRC grouped by C11orf58-low versus C11orf58-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C11orf58→partner) and Y-score (partner→C11orf58) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TFRC →	+0.704	+2.115	.002	.019	3	2
UCEC	14-3-3_beta →	-0.089	-2.973	.043	.035	3	1
UCEC	EGFR_pY1068 →	-0.257	-2.115	.019	.019	3	1
UCEC	eIF4E →	+0.246	+3.335	.007	.005	3	1
UCEC	A-Raf_pS299 →	-0.177	-2.999	<.001	.035	3	1
UCEC	GAPDH →	+0.638	+2.807	.006	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

TFRC by C11orf58 expression — UCEC

Explore this box plot interactively →