C11orf58

Across TCGA cell cohorts, C11orf58 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,953 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible C11orf58-associated GO terms across cancer lineages are Telomere tethering at nuclear periphery, Endodermal cell fate commitment, and Regulation of microtubule cytoskeleton organization. Each is linked with C11orf58 in more than 11 cancer types. Because this analysis shows association rather than direction, both C11orf58-to-partner and partner-to-C11orf58 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Telomere tethering at nuclear periphery grouped by C11orf58-low versus C11orf58-high in URINARY_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (C11orf58→partner) and Y-score (partner→C11orf58) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	Telomere tethering at nuclear periphery →	+0.160	+0.928	<.001	<.001	3	12
STOMACH	Endodermal cell fate commitment →	+0.169	+0.808	<.001	<.001	3	11
BREAST	Regulation of microtubule cytoskeleton organization →	+0.054	+0.889	<.001	<.001	3	10
URINARY_TRACT	Post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery →	+0.103	+0.801	<.001	<.001	3	9
BLOOD_Lymphoma	Regulation of intracellular steroid hormone receptor signaling pathway →	+0.088	+1.291	<.001	<.001	3	9
BLOOD_Lymphoma	Heterochromatin formation →	+0.058	+1.127	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,953 associations by consensus.

Telomere tethering at nuclear periphery by C11orf58 expression — URINARY_TRACT

Explore this box plot interactively →