C11orf53

Across TCGA patient cohorts, C11orf53 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,969 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible C11orf53-associated GO terms across cancer lineages are Sphingoid metabolic process, Otolith development, and Phosphate ion transmembrane transport. Each is linked with C11orf53 in more than 10 cancer types. Because this analysis shows association rather than direction, both C11orf53-to-partner and partner-to-C11orf53 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Sphingoid metabolic process grouped by C11orf53-low versus C11orf53-high in ESCA.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (C11orf53→partner) and Y-score (partner→C11orf53) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ESCA	Sphingoid metabolic process →	+0.059	+1.196	<.001	<.001	3	10
CHOL	Otolith development →	+0.084	+1.582	.001	<.001	2	11
ESCA	Phosphate ion transmembrane transport →	+0.039	+1.193	<.001	<.001	3	10
ESCA	Regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation →	+0.069	+1.307	<.001	<.001	3	10
ESCA	Apoptotic mitochondrial changes →	+0.029	+1.118	.002	<.001	2	11
TGCT	Microvillus organization →	+0.058	+0.214	<.001	<.001	2	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,969 associations by consensus.

Sphingoid metabolic process by C11orf53 expression — ESCA

Explore this box plot interactively →