C11orf53

Across TCGA patient cohorts, C11orf53 mutation is significantly associated with the RNA expression of many other genes, with 208 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible C11orf53-associated genes across cancer lineages are RNU6-694P, PGAM1P13, and RNU6-79P. Each is linked with C11orf53 in more than 1 cancer types. Because this analysis shows association rather than direction, both C11orf53-to-partner and partner-to-C11orf53 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-694P grouped by C11orf53-low versus C11orf53-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C11orf53→partner) and Y-score (partner→C11orf53) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RNU6-694P →	+0.625	+5.478	<.001	<.001	3	2
COAD	PGAM1P13 →	+0.105	+6.149	<.001	<.001	3	2
UCEC	RNU6-79P →	+0.528	+3.246	<.001	.008	3	2
UCEC	HMGB3P15 →	+0.098	+3.450	.004	.005	3	2
UCEC	GYG1P1 →	+0.324	+4.011	<.001	.001	3	2
SKCM	RNU6ATAC39P →	+0.198	+1.963	.003	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 208 associations by consensus.

RNU6-694P by C11orf53 expression — COAD

Explore this box plot interactively →