C11orf53

Across TCGA patient cohorts, C11orf53 mutation is significantly associated with the immune_cell of many other genes, with 4 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C11orf53-associated genes across cancer lineages are GMP, Macrophages M2, and Th2 cells. Each is linked with C11orf53 in more than 1 cancer types. Because this analysis shows association rather than direction, both C11orf53-to-partner and partner-to-C11orf53 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GMP grouped by C11orf53-low versus C11orf53-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C11orf53→partner) and Y-score (partner→C11orf53) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GMP →	+0.079	+3.172	.043	.017	3	2
UCEC	Macrophages M2 →	+0.019	+2.925	.003	.031	3	2
SKCM	Th2 cells →	+0.209	+3.009	.006	.019	3	1
SKCM	Th1 cells →	-0.114	-1.993	.003	.032	2	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

GMP by C11orf53 expression — UCEC

Explore this box plot interactively →