C11orf53

Across TCGA cell cohorts, C11orf53 mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible C11orf53-associated genes across cancer lineages are LGI1, USP29, and KRT71. Each is linked with C11orf53 in more than 1 cancer types. Because this analysis shows association rather than direction, both C11orf53-to-partner and partner-to-C11orf53 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LGI1 grouped by C11orf53-low versus C11orf53-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C11orf53→partner) and Y-score (partner→C11orf53) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	LGI1 →	+0.122	+5.539	<.001	.003	3	1
BLOOD_Leukemia	USP29 →	+0.006	+4.922	<.001	.009	3	1
BLOOD_Leukemia	KRT71 →	+0.066	+4.922	<.001	.009	3	1
BLOOD_Leukemia	TRIM60 →	+0.039	+5.201	<.001	.006	3	1
BLOOD_Leukemia	KRTAP4-9 →	+0.055	+5.201	<.001	.006	3	1
BLOOD_Leukemia	OR6B1 →	+0.013	+5.969	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

LGI1 by C11orf53 expression — BLOOD_Leukemia

Explore this box plot interactively →