C11orf52

Across TCGA pan-cancer cohorts, C11orf52 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated C11orf52 data layer compared with 26 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher C11orf52 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated C11orf52 expression acts as an unfavorable survival marker, although some lineages such as LSCC and LUAD show a favorable association.

LSCC, LUAD, and PDAC are the cancer types where C11orf52 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Quartile	II,III,IV	1.000	0.528	.001	21	view →
LUAD	OS	Quartile	III,IV	0.821	0.387	.019	8	view →
PDAC	OS	Median	III,IV	0.920	0.619	.022	6	view →
CCRCC	OS	Tertile	III,IV	1.000	0.831	.032	4	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

C11orf52–LSCC (DFS)

Open the LSCC breakdown →