C11orf52

Across TCGA cell cohorts, C11orf52 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,565 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible C11orf52-associated GO terms across cancer lineages are Positive regulation of Rho protein signal transduction, Negative regulation of G protein-coupled receptor signaling pathway, and Norrin signaling pathway. Each is linked with C11orf52 in more than 11 cancer types. Because this analysis shows association rather than direction, both C11orf52-to-partner and partner-to-C11orf52 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of Rho protein signal transduction grouped by C11orf52-low versus C11orf52-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (C11orf52→partner) and Y-score (partner→C11orf52) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Positive regulation of Rho protein signal transduction →	+0.137	+1.898	<.001	<.001	3	12
LUNG_NSCLC_LUSC	Negative regulation of G protein-coupled receptor signaling pathway →	-0.075	-1.409	.002	<.001	3	11
OVARY	Norrin signaling pathway →	+0.472	+1.497	.005	.002	3	10
LUNG_NSCLC_LUSC	Establishment of epithelial cell apical/basal polarity →	-0.196	-1.370	<.001	<.001	3	10
LUNG_SCLC	Sensory perception of salty taste →	+1.558	+1.905	<.001	<.001	3	10
URINARY_TRACT	IMP biosynthetic process →	-0.214	-2.542	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,565 associations by consensus.

Positive regulation of Rho protein signal transduction by C11orf52 expression — STOMACH

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