C11orf49

Across TCGA patient cohorts, C11orf49 mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C11orf49-associated genes across cancer lineages are Cyclin-E2, Ku80, and p62 Lck ligand. Each is linked with C11orf49 in more than 1 cancer types. Because this analysis shows association rather than direction, both C11orf49-to-partner and partner-to-C11orf49 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-E2 grouped by C11orf49-low versus C11orf49-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C11orf49→partner) and Y-score (partner→C11orf49) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-E2 →	+0.207	+3.169	.025	.020	3	2
UCEC	Ku80 →	+0.299	+2.820	.021	.035	3	1
UCEC	p62 Lck ligand →	+0.421	+3.169	.018	.020	3	1
UCEC	STAT3_pY705 →	-0.410	-2.990	.004	.036	3	1
UCEC	RBM15 →	+0.362	+3.183	.038	.010	2	1
UCEC	VHL →	-1.427	-3.169	<.001	.020	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

Cyclin-E2 by C11orf49 expression — UCEC

Explore this box plot interactively →