C11orf42

Across TCGA patient cohorts, C11orf42 mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C11orf42-associated genes across cancer lineages are Notch1, VHL, and Bak. Each is linked with C11orf42 in more than 1 cancer types. Because this analysis shows association rather than direction, both C11orf42-to-partner and partner-to-C11orf42 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by C11orf42-low versus C11orf42-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C11orf42→partner) and Y-score (partner→C11orf42) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.222	+2.183	<.001	.033	3	2
UCEC	VHL →	-1.319	-2.584	<.001	.010	3	2
UCEC	Bak →	+0.281	+2.700	.012	.006	3	2
SKCM	Chk1 →	+0.285	+3.034	.009	.018	3	1
UCEC	eEF2 →	+0.350	+3.169	.030	.018	3	1
UCEC	A-Raf_pS299 →	-0.166	-3.321	.002	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

Notch1 by C11orf42 expression — UCEC

Explore this box plot interactively →