C11orf24

Across TCGA patient cohorts, C11orf24 mutation is significantly associated with the total protein of many other genes, with 12 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C11orf24-associated genes across cancer lineages are Cyclin-B1, Cyclin-E2, and ACC_pS79. Each is linked with C11orf24 in more than 1 cancer types. Because this analysis shows association rather than direction, both C11orf24-to-partner and partner-to-C11orf24 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by C11orf24-low versus C11orf24-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C11orf24→partner) and Y-score (partner→C11orf24) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.626	+3.000	.016	.036	3	2
UCEC	Cyclin-E2 →	+0.158	+2.584	.043	.011	3	2
UCEC	ACC_pS79 →	+0.365	+3.009	.023	.019	3	1
UCEC	Ku80 →	+0.236	+1.887	.032	.031	3	1
UCEC	p62 Lck ligand →	+0.401	+2.179	.008	.034	3	1
UCEC	Smad4 →	-0.135	-2.584	.016	.011	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

Cyclin-B1 by C11orf24 expression — UCEC

Explore this box plot interactively →