C11orf16

Across TCGA patient cohorts, C11orf16 mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C11orf16-associated genes across cancer lineages are eIF4G, ERK2, and Myosin-IIa_pS1943. Each is linked with C11orf16 in more than 1 cancer types. Because this analysis shows association rather than direction, both C11orf16-to-partner and partner-to-C11orf16 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4G grouped by C11orf16-low versus C11orf16-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C11orf16→partner) and Y-score (partner→C11orf16) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4G →	+0.323	+2.321	.038	.035	3	1
UCEC	ERK2 →	+0.259	+2.321	.007	.035	3	1
UCEC	Myosin-IIa_pS1943 →	+0.231	+3.169	.026	.019	3	1
UCEC	Notch1 →	+0.166	+2.321	.018	.035	3	1
UCEC	p62 Lck ligand →	+0.618	+2.179	<.001	.034	3	1
UCEC	PCNA →	+0.291	+2.321	.007	.035	2	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

eIF4G by C11orf16 expression — UCEC

Explore this box plot interactively →