C11orf1

Across TCGA pan-cancer cohorts, C11orf1 mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of C11orf1’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where C11orf1 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types C11orf1 is over-expressed in tumor, although a few such as CCRCC and COAD show the opposite, repressed pattern.

LSCC, LUAD, and CCRCC are the cancer types where C11orf1 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in C11orf1 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LSCC	Male	II,III,IV	+0.429	<.001	8	view →
LUAD	Male	II,III,IV	+0.201	<.001	8	view →
CCRCC	Female	III,IV	−0.273	<.001	7	view →
PDAC	All	II,III,IV	+0.405	<.001	6	view →
COAD	Female	IV	−0.177	.042	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

C11orf1–LSCC

Open the LSCC breakdown →