C11orf1

Across TCGA patient cohorts, C11orf1 mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C11orf1-associated genes across cancer lineages are p38-MAPK_pT180_Y182, PDCD4, and Annexin_VII. Each is linked with C11orf1 in more than 1 cancer types. Because this analysis shows association rather than direction, both C11orf1-to-partner and partner-to-C11orf1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p38-MAPK_pT180_Y182 grouped by C11orf1-low versus C11orf1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C11orf1→partner) and Y-score (partner→C11orf1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p38-MAPK_pT180_Y182 →	-0.558	-2.986	.031	.037	3	1
UCEC	PDCD4 →	-0.775	-3.000	.004	.037	3	1
UCEC	Annexin_VII →	-0.173	-3.000	.031	.037	3	1
UCEC	Smad3 →	+0.179	+3.000	.040	.037	3	1
UCEC	Bak →	+0.306	+3.000	.034	.037	3	1
UCEC	Cyclin-E2 →	+0.226	+3.000	.020	.037	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

p38-MAPK_pT180_Y182 by C11orf1 expression — UCEC

Explore this box plot interactively →