C10orf90

Across TCGA patient cohorts, C10orf90 mutation is significantly associated with the total protein of many other genes, with 70 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C10orf90-associated genes across cancer lineages are Cyclin-E2, MIG-6, and Gab2. Each is linked with C10orf90 in more than 5 cancer types. Because this analysis shows association rather than direction, both C10orf90-to-partner and partner-to-C10orf90 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-E2 grouped by C10orf90-low versus C10orf90-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C10orf90→partner) and Y-score (partner→C10orf90) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Cyclin-E2 →	+0.197	+2.708	.036	.003	3	6
BLCA	MIG-6 →	+0.191	+3.321	<.001	.010	3	3
STAD	Gab2 →	+0.446	+3.000	.033	.034	3	3
COAD	A-Raf_pS299 →	-0.184	-1.991	.007	.031	3	3
COAD	JNK_pT183_Y185 →	-0.209	-2.321	.048	.033	3	3
UCEC	MEK1 →	+0.343	+1.938	.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 70 associations by consensus.

Cyclin-E2 by C10orf90 expression — COAD

Explore this box plot interactively →