C10orf67

Across TCGA patient cohorts, C10orf67 mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C10orf67-associated genes across cancer lineages are GATA6, GSK-3a-b_pS21_S9, and INPP4B. Each is linked with C10orf67 in more than 1 cancer types. Because this analysis shows association rather than direction, both C10orf67-to-partner and partner-to-C10orf67 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GATA6 grouped by C10orf67-low versus C10orf67-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C10orf67→partner) and Y-score (partner→C10orf67) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GATA6 →	-0.217	-2.992	.014	.036	3	1
UCEC	GSK-3a-b_pS21_S9 →	+0.702	+2.817	.004	.036	3	1
UCEC	INPP4B →	-0.378	-3.000	.043	.036	3	1
UCEC	JNK2 →	+0.405	+3.000	<.001	.037	3	1
UCEC	Tuberin_pT1462 →	+0.520	+2.817	<.001	.036	3	1
UCEC	Ku80 →	+0.319	+3.013	.019	.019	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

GATA6 by C10orf67 expression — UCEC

Explore this box plot interactively →