C10orf53

Across TCGA patient cohorts, C10orf53 mutation is significantly associated with the RNA expression of many other genes, with 1,723 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C10orf53-associated genes across cancer lineages are VDAC2, COMTD1, and GHITM. Each is linked with C10orf53 in more than 2 cancer types. Because this analysis shows association rather than direction, both C10orf53-to-partner and partner-to-C10orf53 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, VDAC2 grouped by C10orf53-low versus C10orf53-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C10orf53→partner) and Y-score (partner→C10orf53) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	VDAC2 →	+0.481	+3.510	.001	.002	3	3
LUSC	COMTD1 →	+0.826	+3.700	<.001	.001	3	3
UCEC	GHITM →	+0.551	+2.247	.002	.002	3	3
UCEC	ITGB1BP1 →	+0.336	+2.338	.005	.003	3	3
SKCM	PCBD1 →	+0.544	+3.082	<.001	<.001	3	3
COAD	MIR6815 →	+0.253	+4.824	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,723 associations by consensus.

VDAC2 by C10orf53 expression — SKCM

Explore this box plot interactively →