C10orf53

Across TCGA patient cohorts, C10orf53 mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C10orf53-associated genes across cancer lineages are Caspase-7-cleavedD198, MYH11, and ERK2. Each is linked with C10orf53 in more than 1 cancer types. Because this analysis shows association rather than direction, both C10orf53-to-partner and partner-to-C10orf53 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by C10orf53-low versus C10orf53-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C10orf53→partner) and Y-score (partner→C10orf53) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.626	+2.135	.005	.010	3	2
LUSC	MYH11 →	-1.141	-2.990	.019	.036	3	1
UCEC	ERK2 →	+0.236	+2.115	.001	.016	3	1
UCEC	MSH2 →	-0.228	-1.848	.009	.049	3	1
UCEC	p21 →	+0.161	+2.820	.029	.035	3	1
UCEC	Rab25 →	-0.272	-2.999	.032	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

Caspase-7-cleavedD198 by C10orf53 expression — UCEC

Explore this box plot interactively →