C10orf53

Across TCGA cell cohorts, C10orf53 mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. STOMACH shows the largest number of these associations.

The most reproducible C10orf53-associated genes across cancer lineages are GGTLC2, FCN2, and FAM71C. Each is linked with C10orf53 in more than 1 cancer types. Because this analysis shows association rather than direction, both C10orf53-to-partner and partner-to-C10orf53 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GGTLC2 grouped by C10orf53-low versus C10orf53-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C10orf53→partner) and Y-score (partner→C10orf53) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	GGTLC2 →	+0.032	+4.273	<.001	.006	3	1
SKIN	FCN2 →	+0.045	+5.022	<.001	.002	3	1
SKIN	FAM71C →	+0.017	+4.095	<.001	.009	3	1
STOMACH	CRX →	+0.042	+3.830	<.001	.005	3	1
STOMACH	MS4A4A →	+0.154	+3.736	<.001	.006	3	1
STOMACH	LILRB2 →	+0.048	+3.432	.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

GGTLC2 by C10orf53 expression — SKIN

Explore this box plot interactively →