Across TCGA patient cohorts, C10orf105 mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C10orf105-associated genes across cancer lineages are GAPDH, JNK_pT183_Y185, and Ku80. Each is linked with C10orf105 in more than 1 cancer types. Because this analysis shows association rather than direction, both C10orf105-to-partner and partner-to-C10orf105 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C10orf105→partner) and Y-score (partner→C10orf105) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GAPDH →	+0.652	+2.999	.020	.035	3	1
UCEC	JNK_pT183_Y185 →	-0.208	-3.308	.018	.010	3	1
UCEC	Ku80 →	+0.320	+2.183	.009	.035	3	1
UCEC	MEK1 →	+0.608	+3.169	.001	.019	3	1
UCEC	PKC-b-II_pS660 →	-0.293	-3.000	.043	.036	3	1
UCEC	STAT3_pY705 →	-0.474	-2.990	<.001	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

Exploration

C10orf105 survival (RNA) · tumor vs normal (RNA) · all C10orf105 data types