BZW1

Across TCGA cell cohorts, BZW1 mutation is significantly associated with the mutation status of many other genes, with 4,145 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible BZW1-associated genes across cancer lineages are CDK12, DIS3L, and CHD8. Each is linked with BZW1 in more than 4 cancer types. Because this analysis shows association rather than direction, both BZW1-to-partner and partner-to-BZW1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CDK12 grouped by BZW1-low versus BZW1-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BZW1→partner) and Y-score (partner→BZW1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	CDK12 →	+2.977	+4.392	.005	.005	1	5
BLOOD_Lymphoma	DIS3L →	+5.247	+4.429	.005	.005	1	5
BLOOD_Leukemia	CHD8 →	+2.975	+3.794	.006	.006	1	4
CNS	ADGRB2 →	+4.044	+5.000	.008	.008	1	4
SKIN	CDAN1 →	+4.392	+4.392	.009	.009	1	4
SKIN	IGF1R →	+2.977	+4.392	.005	.005	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,145 associations by consensus.

CDK12 by BZW1 expression — SKIN

Explore this box plot interactively →