BYSL

Across TCGA patient cohorts, BYSL mutation is significantly associated with the total protein of many other genes, with 12 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BYSL-associated genes across cancer lineages are 14-3-3_beta, Myosin-IIa_pS1943, and Caspase-8. Each is linked with BYSL in more than 1 cancer types. Because this analysis shows association rather than direction, both BYSL-to-partner and partner-to-BYSL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by BYSL-low versus BYSL-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BYSL→partner) and Y-score (partner→BYSL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.126	-2.986	.030	.037	3	1
UCEC	Myosin-IIa_pS1943 →	+0.250	+3.013	.036	.019	3	1
UCEC	Caspase-8 →	-0.321	-3.000	.027	.037	3	1
UCEC	eEF2 →	+0.457	+3.000	.027	.037	2	1
UCEC	ERK2 →	+0.252	+3.000	.023	.037	2	1
UCEC	p62 Lck ligand →	+0.526	+2.817	.005	.036	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

14-3-3_beta by BYSL expression — UCEC

Explore this box plot interactively →