BYSL

Across TCGA cell cohorts, BYSL mutation is significantly associated with the drug of many other genes, with 12 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible BYSL-associated genes across cancer lineages are VE-822, Uprosertib, and PRT062607. Each is linked with BYSL in more than 1 cancer types. Because this analysis shows association rather than direction, both BYSL-to-partner and partner-to-BYSL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, VE-822 grouped by BYSL-low versus BYSL-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BYSL→partner) and Y-score (partner→BYSL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	VE-822 →	+0.634	+2.646	.026	.047	3	1
LARGE_INTESTINE	Uprosertib →	+0.635	+2.646	.035	.047	2	1
LARGE_INTESTINE	PRT062607 →	+0.618	+2.769	.013	.040	2	1
LARGE_INTESTINE	GSK2110183B →	+0.645	+2.649	.034	.046	2	1
LARGE_INTESTINE	Sabutoclax →	+0.473	+2.769	.025	.040	2	1
LARGE_INTESTINE	Ara-G →	+0.184	+2.722	.028	.040	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

VE-822 by BYSL expression — LARGE_INTESTINE

Explore this box plot interactively →