BUD23

Across TCGA patient cohorts, BUD23 mutation is significantly associated with the total protein of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BUD23-associated genes across cancer lineages are PDK1_pS241, TIGAR, and MSH2. Each is linked with BUD23 in more than 1 cancer types. Because this analysis shows association rather than direction, both BUD23-to-partner and partner-to-BUD23 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PDK1_pS241 grouped by BUD23-low versus BUD23-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BUD23→partner) and Y-score (partner→BUD23) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PDK1_pS241 →	+0.181	+3.000	.043	.036	3	1
UCEC	TIGAR →	+0.180	+2.196	.024	.034	3	1
UCEC	MSH2 →	-0.393	-2.990	.001	.036	2	1
UCEC	PCNA →	+0.348	+3.000	.002	.036	2	1
UCEC	Rab25 →	-0.538	-3.321	.001	.010	1	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

PDK1_pS241 by BUD23 expression — UCEC

Explore this box plot interactively →