BUD13

Across TCGA patient cohorts, BUD13 mutation is significantly associated with the total protein of many other genes, with 36 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BUD13-associated genes across cancer lineages are JNK_pT183_Y185, PDCD4, and AR. Each is linked with BUD13 in more than 1 cancer types. Because this analysis shows association rather than direction, both BUD13-to-partner and partner-to-BUD13 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK_pT183_Y185 grouped by BUD13-low versus BUD13-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BUD13→partner) and Y-score (partner→BUD13) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK_pT183_Y185 →	-0.195	-1.986	.003	.010	3	2
UCEC	PDCD4 →	-0.575	-1.990	.001	.030	3	2
UCEC	AR →	-0.392	-2.000	.007	.010	3	2
UCEC	TFRC →	+0.457	+1.584	.028	.036	3	2
UCEC	Cyclin-B1 →	+0.616	+2.584	.005	.010	3	2
UCEC	eEF2 →	+0.297	+2.999	.034	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

JNK_pT183_Y185 by BUD13 expression — UCEC

Explore this box plot interactively →