BUB3

Across TCGA pan-cancer cohorts, BUB3 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated BUB3 data layer compared with 27 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher BUB3 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated BUB3 expression acts as an unfavorable survival marker, although some lineages such as LUAD and LSCC show a favorable association.

LUAD, LSCC, and UCEC are the cancer types where BUB3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Tertile	II,III,IV	0.810	0.314	.001	20	view →
LSCC	DFS	Median	II,III,IV	0.847	0.568	.027	8	view →
UCEC	DFS	Median	III,IV	0.460	0.889	.044	4	view →
HNSC	DFS	Quartile	II,III,IV	0.979	0.860	.032	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

BUB3–LUAD (OS)

Open the LUAD breakdown →