BUB3

Across TCGA patient cohorts, BUB3 mutation is significantly associated with the RNA expression of many other genes, with 2,312 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BUB3-associated genes across cancer lineages are RNA5SP361, CCDC163, and LINC01943. Each is linked with BUB3 in more than 1 cancer types. Because this analysis shows association rather than direction, both BUB3-to-partner and partner-to-BUB3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP361 grouped by BUB3-low versus BUB3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BUB3→partner) and Y-score (partner→BUB3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP361 →	+0.114	+2.938	<.001	.006	3	2
UCEC	CCDC163 →	+0.474	+2.337	<.001	.003	3	1
UCEC	LINC01943 →	+0.361	+2.102	.005	.001	3	1
UCEC	RASSF1-AS1 →	+0.579	+3.743	<.001	<.001	3	1
UCEC	RBM5-AS1 →	+0.234	+2.711	<.001	.003	3	1
UCEC	PACRG-AS1 →	-0.130	-2.491	.008	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,312 associations by consensus.

RNA5SP361 by BUB3 expression — UCEC

Explore this box plot interactively →